Host Defense Mechanisms against Infection with Influenza Virus. I. Effect of Sensitized Spleen Cells on Infection in Vitro
Identifieur interne : 002C12 ( Main/Exploration ); précédent : 002C11; suivant : 002C13Host Defense Mechanisms against Infection with Influenza Virus. I. Effect of Sensitized Spleen Cells on Infection in Vitro
Auteurs : Francis A. Ennis [États-Unis] ; William A. Ruth [États-Unis] ; Martha A. Wells [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1974.
Abstract
Sensitized murine spleen cells decrease the spread of influenza infection in cell cultures derived from human and syngeneic murine tissues. This control of infection is immune-specific and can be induced by immunization with identical hemagglutinin or neuraminidase antigens. The antiviral effect is evident in the absence of added immune serum and can be blocked by adsorption of sensitized spleen cells with antiserum to murine IgG. The antiviral effect persists despite separation by agar of the sensitized spleen cells from the virus-infected monolayer. Spleen cells that do not adhere to glass are quantitatively more capable of limiting the spread of influenza virus in cell culture than are glass-adhering cells. These results suggest that mice immunized with influenza virus have sensitized spleen cells that elaborate antibody to influenza virus, which can act locally to control the spread of infection.
Url:
DOI: 10.1093/infdis/130.3.248
Affiliations:
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Wells</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1974-09">1974</date><biblScope unit="vol">130</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="248">248</biblScope><biblScope unit="page" to="256">256</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Sensitized murine spleen cells decrease the spread of influenza infection in cell cultures derived from human and syngeneic murine tissues. This control of infection is immune-specific and can be induced by immunization with identical hemagglutinin or neuraminidase antigens. The antiviral effect is evident in the absence of added immune serum and can be blocked by adsorption of sensitized spleen cells with antiserum to murine IgG. The antiviral effect persists despite separation by agar of the sensitized spleen cells from the virus-infected monolayer. Spleen cells that do not adhere to glass are quantitatively more capable of limiting the spread of influenza virus in cell culture than are glass-adhering cells. These results suggest that mice immunized with influenza virus have sensitized spleen cells that elaborate antibody to influenza virus, which can act locally to control the spread of infection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name></region><name sortKey="Ruth, William A" sort="Ruth, William A" uniqKey="Ruth W" first="William A." last="Ruth">William A. Ruth</name><name sortKey="Wells, Martha A" sort="Wells, Martha A" uniqKey="Wells M" first="Martha A." last="Wells">Martha A. Wells</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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